Which of the following schedules includes substances with a high potential for abuse and severe dependence but has recognized medical use?

Schedule II substances are categorized as having a high potential for abuse and can lead to severe psychological or physical dependence. However, they also have accepted medical uses in the United States. This means that while they are considered dangerous, their medicinal value is recognized, and they can be prescribed by healthcare professionals for specific medical conditions.

Examples of Schedule II substances include drugs such as morphine and oxycodone, which are effective for pain management but require strict regulation due to their potential for abuse and addiction. This schedule contrasts with Schedule I substances, which have no accepted medical use and are deemed to have the highest potential for abuse. Schedules III and IV contain substances with lower abuse potential and milder dependence risks than those in Schedule II. Thus, the unique combination of high abuse potential alongside recognized medical use confirms the classification of certain substances under Schedule II.